Medication

Facts – Diabetes medications can help people drink less alcohol


Thursday 14 November 2024

New research, led by experts at the University of Nottingham, has found that certain types of drugs used to treat diabetes may be effective in reducing alcohol consumption.

Study, published in eClinicalMedicinelooked at whether a type of diabetes medication, called GLP-1 receptor agonists (GLP-1 RAs), could also be used to help people reduce their intake.

The study was led by Dr Mohsen Subhani, Clinical Assistant Professor of Gastroenterology at the NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham. It was funded by the National Institute for Health and Care Research (NIHR) and the Biomedical Research Institute NIHR Nottingham.


In the new study, researchers reviewed the existing literature on the use of GLP-1 RAs and change in alcohol use.

They collected studies through August 2024 that examined whether GLP-1 RAs affect alcohol consumption, alcohol-related health problems, hospital visits, and the brain’s response to intoxication. The group evaluated six articles, including two randomized control trials conducted by 88,190 participants, of which 38,740 (43.9%) of the participants received GLP-1RA.

Our findings show that this type of diabetes medication shows promise in reducing alcohol consumption, possibly by targeting the reward center of the brain, especially in people with BMI above 30.”


Dr Mohsen Subhani, Clinical Associate Professor of Gastroenterology at the Biomedical Research Institute NIHR Nottingham, School of Medicine.

Key results:

  • In one large study, exenatide medication did not reduce overall drinking after six months, but obese people showed better results.
  • Another study found that people taking the drug dulaglutide were 29% more likely to reduce their drinking than those taking a placebo.
  • Observational (randomized) studies have shown fewer alcohol-related health problems and lower alcohol consumption in people taking GLP-1 RAs compared to other treatments.

Although further research is needed, our findings suggest that this may be a future treatment option for alcohol abuse and may subsequently lead to a reduction in morbidity and mortality. alcohol,” added Dr Subhani.

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The DOI for this paper will be 10.1016/j.eclinm.2024.102920

Additional information available from Dr. Mohsen Subhani from School of Medicine to mohsan.subhani@nottingham.ac.uk

CharlotteAncombe

Notes to editors:

About the University of Nottingham

Ranked 32nd in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, born out of the vision of our founder Sir Jesse Boot, which has seen us take the lead in establishing campuses in China and Malaysia – part of an interconnected global network of education, research and industry engagement.

Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been awarded the honor since 2018 – and by the Daily Mail University Guide 2024.

The university is one of the best universities in the UK for our research strength, ranked seventh for research strength in the UK according to REF 2021. Birthplace of discoveries such as MRI and ibuprofen , our innovations are changing lives and addressing global challenges such as sustainable food supply, ending modern slavery, developing green transportation, and reducing dependence on fossil fuels. old.

The University is a leading employer and industry partner – locally and globally – and our graduates are the second most sought after by top employers in the UK, according to The Graduate Market in 2022 report by High Fliers Research .

We are leading the Nottingham Universities Programme, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, resilience, health and well-being to the residents of the city and the environment we are proud of. call home.

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